The church was built in 1568 by the Portuguese. The oldest church was renovated in 1910 in Roman design of architecture. It is near a place called Hampankatta in Mangalore city in a calm and silent locality.
In the year 1910 the parish priest by the name Fr.H.I. Busoni demolished the old building and started the work on a new structure. The cathedral also runs a high school called Rosario High School. It also runs St. Vincent Paul society meant for the upliftment of the poor and the downtrodden.
The church had always faced threats and its soul always outlived the threats and damages. The building as completely squandered by Tipu Sultan's forces in 1784 as it was a church started by a foreign force.
The Cathedral has a dome and the cross on the dome was lit every night serving as a beacon for seafarers. It is also believed that the image of Virgin Mary on the altar was found by the fishermen when it got caught in the net. There is a lot of history attached to this and it makes a place worth visiting once.