Driving down from Mumbai to Ganpatipule is a great option. The roads and ghats are well made, while the surroundings are charismatic. The distance is around 326 km. It is just a few km before Ratnagiri on the road from Mumbai to Goa. There are also state-run and MTDC buses available that are not only economically viable but comfortable too. The MSRTC undertakes a daily journey from to Ganpatipule from Mumbai. One can opt for cabs too.
Head northwest on Vittal Mallya Rd toward Kasturba Rd
Turn left onto Kasturba Rd/Rajaram Mohan Roy Rd/Vittal Mallya Rd
Turn right toward Krishna Rajendra Cir
Turn left toward Krishna Rajendra Cir
Turn left onto Krishna Rajendra Cir
Take the 1st right to stay on Krishna Rajendra Cir
Krishna Rajendra Cir turns slightly left and becomes Seshadri Rd
Turn right at ganesha temple onto SC Road
Turn left at Free Reading Room onto Nagappa Rd
Turn right at Hotel Green Orchid onto Platform Rd
At H P Petrol Pump, continue onto Sampige Rd
Turn left after the park (on the right)
Turn right at Deepak Sahakari Bank onto 7th Main Rd/Sri M Ramamurthy Rd
At Ayyappa Temple, continue onto 1st Main Rd
Slight left onto Tumkur Road
Continue onto Asian Highway 47/NH 4
Continue straight to stay on Asian Highway 47/NH 4
Keep left to continue on Tumkur - GG Halli Rd
Continue onto Asian Highway 47/NH 4
Take the exit
Continue straight
Slight left onto Old Pune-Bangalore Hwy
At the roundabout, take the 1st exit onto Station Rd
At the roundabout, take the 3rd exit onto राज्य महामार्ग क्र. २०४/NH 204
Turn right onto राज्य महामार्ग क्र. २०४/MH SH 275/NH 204
Sharp right toward Mumbai-Goa Road
Turn right onto Mumbai-Goa Road
Turn left onto SH106
Turn right at Tiwarad Fata to stay on SH106
Slight left onto MDR37
Turn right
Take the 1st left
Turn right